Microneedling








Real Results
Results achieved through customized microneeedling treatment plans
PDRN (Salmon DNA) Regenerative Therapy
How Plastic Surgeons Use PDRN
Plastic surgeons and regenerative medicine specialists increasingly utilize PDRN as a supportive therapy during recovery and tissue regeneration procedures. Research has investigated its role in improving wound healing, supporting tissue repair, and enhancing the survival of transplanted fat during fat-grafting procedures. Because healthy blood supply is critical to fat graft survival, regenerative therapies such as PDRN are being studied for their ability to support vascularization and tissue integration.
(PubMed (https://pubmed.ncbi.nlm.nih.gov/33966905
While PDRN itself is not a breast augmentation treatment, regenerative surgeons have explored its use alongside fat-transfer procedures to help support healing and optimize tissue quality.
(PubMed (https://pubmed.ncbi.nlm.nih.gov/33966905
Why We Combine PDRN with Microneedling
Microneedling creates controlled microchannels in the skin that stimulate the body’s natural healing response. When combined with PDRN, these channels may enhance delivery of regenerative ingredients into the skin while simultaneously stimulating collagen production.
This combination improves:
• Fine lines and wrinkles
• Acne scars
• Skin texture and tone
• Enlarged pores
• Sun damage
• Skin hydration and radiance
• Post-inflammatory redness
• Overall skin quality and resilience
PDRN-enhanced microneedling has become a popular regenerative treatment because it supports both collagen remodeling and tissue repair.
(Yoo Direct Health (https://www.yoodirecthealth.com/blog/pdrn-and-microneedling-the-ultimate-duo-for-skin-regeneration-and-longevity
What Is PDRN?
PDRN (Polydeoxyribonucleotide) is a highly purified DNA extract derived from salmon. In regenerative medicine, PDRN has been studied for its ability to support tissue repair, reduce inflammation, stimulate fibroblast activity, promote collagen production, and encourage healthy blood vessel formation. Originally developed for wound healing and tissue regeneration, PDRN has become one of the most exciting innovations in aesthetic medicine.
(PMC (https://pmc.ncbi.nlm.nih.gov/articles/PMC8618295
How Does PDRN Work?
PDRN works by providing biological building blocks that support cellular repair and regeneration. Research suggests it activates pathways involved in tissue healing, fibroblast stimulation, collagen synthesis, and microcirculation. These regenerative effects help improve skin quality, elasticity, hydration, and overall tissue health.
(MDPI (https://www.mdpi.com/1424-8247/14/11/1103
Why Is PDRN Called “Salmon DNA”?
The DNA fragments used in PDRN are purified from salmon because salmon DNA is highly biocompatible with human tissue. These fragments are processed and purified for medical use and have been utilized in wound healing, tissue repair, and aesthetic medicine for many years.
(Prevention (https://www.prevention.com/beauty/skin-care/a71496120/what-is-pdrn-skincare
PDRN and Facial Rejuvenation
As we age, collagen, elastin, hydration, and structural support within the skin gradually decline. Research has shown that PDRN may help improve skin texture, elasticity, hydration, and overall skin quality through its regenerative effects. Patients often notice healthier, firmer, more radiant skin with improved recovery following aesthetic procedures.
(MDPI (https://www.mdpi.com/1422-0067/25/15/8224
Emerging research in regenerative aesthetics has also explored the use of polynucleotides in areas affected by volume loss. Studies have demonstrated improvement in tissue quality and restoration of soft tissue defects, making PDRN an exciting option for age-related facial changes.
Who Is a Good Candidate?
PDRN is beneficial for patients seeking:
• Natural skin rejuvenation
• Improved skin texture and elasticity
• Reduction in scarring & stretch marks
• Reduction in visible signs of aging
• Support for skin & Hair healing and regeneration
The Future of Regenerative Aesthetics
PDRN represents a new generation of regenerative treatments focused on helping the skin repair itself rather than simply masking signs of aging. Ongoing research continues to investigate its applications in tissue engineering, wound healing, skin rejuvenation, hair restoration, and regenerative medicine.
Frequently Asked Questions
What is microneedling?
Microneedling is a minimally invasive skin treatment that uses tiny sterile needles to create controlled micro-injuries in the skin. This stimulates your body’s natural healing response and boosts collagen and elastin production for smoother, healthier-looking skin.
What does microneedling help treat?
Microneedling can improve:
Fine lines and wrinkles
Acne scars and other scarring
Enlarged pores
Uneven skin texture
Sun damage
Stretch marks
Hyperpigmentation
Mild skin laxity
How does microneedling work?
The treatment creates microscopic channels in the skin, triggering collagen remodeling and cellular renewal. This process helps strengthen and rejuvenate the skin over time.
Is microneedling painful?
Most clients tolerate microneedling very well. A topical numbing cream is typically applied before treatment to minimize discomfort. You may feel mild pressure or a light scratching sensation during the procedure.
What areas can be treated?
Microneedling is commonly performed on the:
Face
Neck
Chest
Hands
Scalp
Stretch mark areas on the body
How long does the treatment take?
Appointments usually take about 45–75 minutes, depending on the treatment area and whether numbing is applied.
What is downtime like?
You may experience redness, warmth, and mild sensitivity similar to a sunburn for 24–72 hours. Some clients also notice slight swelling or dryness as the skin heals.
When will I see results?
Many clients notice a glow and smoother skin within a week. Collagen production continues over several weeks, with the best results typically appearing after multiple treatments.
How many treatments will I need?
This depends on your skin goals and concerns:
General rejuvenation: 3–4 sessions
Acne scarring: 4–6+ sessions
Deeper wrinkles or texture concerns: multiple sessions may be recommended
Treatments are usually spaced 4–6 weeks apart.
Can microneedling help acne scars?
Yes. Microneedling is one of the most popular treatments for acne scarring because it helps remodel damaged collagen and smooth uneven texture over time.
Can microneedling be combined with other treatments?
Yes. Microneedling is often paired with:
Growth factors
Peptides
PRP (“vampire facial”)
LED light therapy
Specialized serums
Your provider will recommend the best combination for your skin goals.
Is microneedling safe for all skin types?
Microneedling is generally safe for most skin tones and types when performed properly. A consultation is important to determine if you are a good candidate.
Who should avoid microneedling?
Microneedling may not be recommended if you have:
Active acne breakouts
Skin infections
Open wounds
Certain skin conditions
Recent isotretinoin (Accutane) use
Pregnancy (depending on protocols)
What should I avoid before treatment?
For several days before your appointment, avoid:
Excessive sun exposure
Retinoids or harsh exfoliants
Waxing or aggressive treatments
Self-tanner on the treatment area
What should I avoid after treatment?
After microneedling, avoid for 24–72 hours:
Heavy sweating or intense workouts
Swimming pools and saunas
Makeup (if advised by your provider)
Direct sun exposure
Harsh skincare products
Can I wear makeup after microneedling?
Most providers recommend waiting at least 24 hours before applying makeup to allow the skin to heal properly.
Is there an age requirement?
Microneedling is typically recommended for adults. Younger clients may be candidates for acne scarring or other skin concerns after consultation.
Is microneedling worth it?
Many clients love microneedling because it improves overall skin quality naturally by stimulating your body’s own collagen production with minimal downtime.
How should I prepare for my appointment?
Come to your appointment with clean skin and avoid wearing heavy makeup or active skincare products. Staying hydrated can also support healing and results.
Safety and Efficacy?
Yes. We utilize medical-grade FDA-cleared microneedling technology for safe, clinically backed skin rejuvenation.
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(317) 399-4637
Opening hours
Monday: Closed
Tuesday: 9:00 am - 7 pm
Wednesday: 9:00 am - 7 pm
Thursday: Closed
Friday: 9:00 am - 7 pm
Saturday: 9:00 am - 5 pm
Sunday: 11:00 am - 5 pm
